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RECENT PUBLICATIONS (2012-2016)

Recent Achievements (2012-2016)

  1. See, EYS; Toh, SL; Goh, JCH. Simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell sheets and silk scaffolds for annulus fibrosus regeneration. Journal Of Tissue Engineering And Regenerative Medicine  2012 Volume: 6   Issue: 7   Pages: 528-535

  2. S.L. Toh, J.C. Goh. Use of Silk in Tendon/Ligament Tissue Engineering. Silk: Properties, Production and Uses. 1st ed. New York: Nova Science Publishers, 30 May 2012; ISBN-10: 1621006921; ISBN-13: 978-1621006923.

  3. Chen K, Sahoo S, He P, Ng KS, Toh SL, Goh JC. A Hybrid Silk/RADA-Based Fibrous Scaffold with Triple Hierarchy for Ligament Regeneration. Tissue engineering Part A. 2012  Volume: 18   Issue: 13-14   Pages: 1399-1409  

  4. Chen K, Ravi S, Toh SL, Goh JC. Osteochondral Interface Generation by Rabbit Bone Marrow Stromal Cells and Osteoblasts Co-culture. Tissue engineering Part A. 2012 Volume: 18   Issue: 17-18   Pages: 1902-1911

  5. He, PF; Ng, KS; Toh, SL; Goh, JCH. In Vitro Ligament-Bone Interface Regeneration Using a Trilineage Coculture System on a Hybrid Silk Scaffold.  Biomacromolecules  2012 Volume: 13   Issue: 9   Pages: 2692-2703  

  6. Abbah, SA; Liu, J; Lam, RWM; Goh, JCH; Wong, HK. In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template. Journal of Controlled Release 2012 Volume: 162   Issue: 2   Pages: 364-372

  7. He P, Sahoo S, Ng KS, Chen K, Toh SL, Goh JC. Enhanced osteoinductivity and osteoconductivity through hydroxyapatite coating of silk-based tissue-engineered ligament scaffold. J Biomed Mater Res A. 2013 Feb;101(2):555-66.

  8. Abbah, SA; Liu, J; Goh, JCH; Wong, HK. Enhanced Control of In Vivo Bone Formation with Surface Functionalized Alginate Microbeads Incorporating Heparin and Human Bone Morphogenetic Protein-2. Tissue Engineering Part A 2013 Volume: 19   Issue: 3-4   Pages: 350-359

  9. Chen, XL; Goh, JCH; Teoh, SH; Das De, S; Soong, R; Lee, T. Localized sclerotic bone response demonstrated reduced nanomechanical creep properties. Journal Of The Mechanical Behavior Of Biomedical Materials 2013 Volume: 17   Pages: 198-208

  10. Abbah, S A, W M R Lam, T Hu, J C H Goh And H K Wong*, "Sequestration Of Rhbmp-2 Into Self-Assembled Polyelectrolyte Complexes Promotes Anatomic Localization Of New Bone In A Porcine Model Of Spinal Reconstructive Surgery". Tissue Engineering, 20, No. 11-12 (2013): 1679-88. (United States).

  11. Shi, P, S A Abbah, Saran Kushagra, Y Zhang, J Li, H K Wong and J C H Goh, "Silk Fibroin-Based Complex Particles with Bioactive Encrustation For Bone Morphogenetic Protein 2 Delivery". Biomacromolecules, 4, No. 12 (2013): 4465-74. (United States).

  12. He, M, Aw Gan, A Y T Lim, J C H Goh, H P Hui, E H Lee and K S A Chong, "The Effect of Fibrin Glue On Tendon Healing And Adhesion Formation In A Rabbit Model Of Flexor Tendon Injury And Repair". Journal of Plastic Surgery and Hand Surgery, 47, No. 6 (2013): 509-12. (Sweden).

  13. Shi*, P,  S L Toh and J C H Goh, "Variation Of The Effect Of Calcium Phosphate Enhancement Of Implanted Silk Fibroin Ligament Bone Integration". Biomaterials, 34, No. 24 (2013): 5947-5957. (United Kingdom).

  14. Wang, M, S A Abbah, T Hu, S Y Toh, W M R Lam, J C H Goh And H K Wong, "Minimizing The Severity Of Rhbmp-2 Induced Inflammation And Heterotopic Ossification With A Polyelectrolyte Carrier Incorporating Heparin On Microbead Templates". Spine, 38, No. 17 (2013): 1452-8. (United States).

  15. Tan*, P, S S Chia, S L Toh, J C H Goh and S S Nathan, "Three-Dimensional Spatial Configuration Of Tumour Cells Confers Resistance To Chemotherapy Independent Of Drug Delivery". Journal Of Tissue Engineering And Regenerative Medicine, (2013). (United Kingdom).

  16. Mokhtarzadeh*, H, C H Yeow, J C H Goh, D Oetomo, F Malekipour And P V S Lee, "Contributions Of The Soleus And Gastrocnemius Muscles To The Anterior Cruciate Ligament Loading During Single-Leg Landing". Journal of Biomechanics, 46, No. 11 (2013): 1913-1920. (United Kingdom).

  17. Neo*, P Y, E Y S See, S L Toh and J C H Goh, "Temporal Profiling Of The Growth And Multi-Lineage Potentiality Of Adipose Tissue-Derived Mesenchymal Stem Cells Cell-Sheets" Journal Of Tissue Engineering And Regenerative Medicine, (2013). (United Kingdom).

  18. S L Toh and J C H Goh, "Aligned Fibrous Scaffolds For Enhanced Mechanoresponse And Tenogenesis Of Mesenchymal Stem Cells". Tissue Engineering Part A, 19, No. 11-12 (2013): 1360-72. (United States).

  19. Chen*, K, K S Ng, S Ravi, J C H Goh And S L Toh, "In Vitro Generation Of Whole Osteochondral Constructs Using Rabbit Bone Marrow Stromal Cells, Employing A Two-Chambered Co-Culture Well Design.". Journal Of Tissue Engineering And Regenerative Medicine, (2013). (United Kingdom).

  20. Chen*, K, P Shi, S L Toh And J C H Goh, "In Vitro Generation Of A Multilayered Osteochondral Construct With An Osteochondral Interface Using Rabbit Bone Marrow Stromal Cells And A Silk Peptide-Based Scaffold". Journal of Tissue Engineering and Regenerative Medicine, (2013). (United Kingdom).

  21. Neo*, P Y, P Shi, J C H Goh and S L Toh, "Characterization and Mechanical Performance Study Of Silk/PVA Cryogels: Towards Nucleus Pulposus Tissue Engineering.". Biomedical Materials, 9, No 6 (2014) (United Kingdom).

  22. Saran*, K, P Shi, R Shashi, J C H Goh and Y Zhang, "A Moldable Putty Containing Silk Fibroin Yolk Shell Particles For Improved Hemostasis And Bone Repair" Advanced Healthcare Materials, 4, No. 3 (2014): 432-445. (United States).

  23. Tan, H S P, S S Chia, S L Toh, J C H Goh and S S Nathan, "The Dominant Role of Il-8 AS an Angiogenic Driver in a Three-Dimensional Physiological Tumor Construct For Drug Testing". Tissue Engineering, 20, No. 11-12 (2014): 1758-1766. (United States).

  24.  J C H Goh and S L Toh, "Controlled Bioactive Molecules Delivery Strategies for Tendon and Ligament Tissue Engineering Using Polymeric Nanofibers". Current Pharmaceutical Design, 21, No. 15 (2015): 1991-2005. (Netherlands).

  25. Wang, M, Sa Abbah, T Hu, W M R Lam, Sy Toh, T Liu, M C Simon, K Bhakoo, J Li, J C H Goh and H K Wong*, "Polyelectrolyte Complex Carrier Enhances Therapeutic Efficiency And Safety Profile Of Bmp-2 In Porcine Lumbar Interbody Fusion Model.". Spine 40 (13), 964-973 (2015). (United States).

  26. Zhang, L, J Albon, H Jones, C L M Gouget, C R Ethier, J C H Goh and M J A Girard*, "Collagen Microstructural Factors Influencing Optic Nerve Head Biomechanics". Investigative Ophthalmology & Visual Science, 56, No. 3 (2015): 2031-42. (United States).

  27. Hu, T, S A Abbah, M Wang, S Y Toh, W M R Lam, N D J Mathanapriya, G Bhakta, M C Simon, K Bhakoo, J Li, J C H Goh And H K Wong*, "Novel Protamine Based Polyelectrolyte Carrier Enhance Low Dose Rhbmp-2 In Posterolateral Spinal Fusion.". Spine 40 (9), 613-621 (2015). (United States).

  28. Neo*, P Y, DJA Tan, P Shi, S L Toh And J C H Goh, "Enhancing Analysis Of Cells And Proteins By Fluorescence Imaging On Silk-Based Biomaterials: Modulating the Autofluorescence Of Silk". Tissue Engineering, Part C: Methods, 21, No. 2 (2015). (United States).

  29. Wang M,   Lam RW,   Abbah SA,   Hu T,   Toh SY,   Cool S,   Bhakoo K,   Li J,   Goh JCH,   Wong HK. Heparin Based Polyelectrolyte Complex Enhances the Therapeutic Efficacy of Bone Morphogenetic Protein-2 for Posterolateral Fusion in a Large Animal Model. 41(15):1199-1207, Spine (2016)

  30. Neo PY, A Sheng, R Taya, MCT Asuncion, SN Png, SL Toh, JCH Goh. Stem cell-derived cell-sheets for connective tissue engineering. Connective Tissue Research, 57(6), 428-442  (2016)

  31. Hu T, SA Abbah, SY Toh, M Wang, RWM Lam, M Naidu, G Bhakta, SM Cool, K Bhakoo, J Li, JCH Goh, HK Wong. Bone marrow-derived mesenchymal stem cells assembled with low-dose BMP-2 in a three-dimensional hybrid construct enhances posterolateral spinal fusion in syngeneic rats. Spine (2016)

  32. Asuncion, M.C.T., Goh, J.C.H., Toh, S.L. Anisotropic silk fibroin/gelatin scaffolds from unidirectional freezing. Materials Science and Engineering C. 67. p 646-656 (2016).

  33. Yap HK, J CH Goh, CH Yeow. A Low-Profile Soft Robotic Sixth-Finger for Grasp Compensation in Hand-Impaired Patient. J. Med. Devices 10(3), 030914 (2016)

  34. J.C. Goh. 266 - Tissue Engineering Approaches to Regeneration of Anterior Cruciate Ligament - Ducheyne, Paul. Comprehensive Biomaterials II. Oxford: Elsevier; 2016 (In preparation)

Achievements: About

PATENTS

US Patent Filed


  1. Goh, C. H. J., Shi, P., Hui, H. P. J., & Li, J. Tissue Interface Augmentation Device for Ligament/Tendon Reconstruction.


TISSUE INTERFACE AUGMENTATION DEVICE FOR LIGAMENT/TENDON RECONSTRUCTION


Publication number: 20160157992


Abstract: The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material.


Type: Application

Filed: July 21, 2014

Publication date: June 9, 2016

Applicants: National University of Singapore, Agency for Science, Technology and Research

Inventors: Cho Hong James GOH,  Pujiang SHI, Hoi Po James HUI, Jun LI


  1. Goh, C. H. J., Shi, P., Wong, H. K., Zhang, Y., Abbah, S. A., & Li, J. Bone Filler Material and Methods of Use.


BONE FILLER MATERIAL AND METHODS OF USE


Publication number: 20150125537


Abstract: There is provided a bone filler material comprising a plurality of particles, each particle comprising a biodegradable outer shell and an inner core. There is also provided an implant prepared from the same, methods of using the same and preparing the same.


Type: Application

Filed: November 7, 2014

Publication date: May 7, 2015

Inventors: Cho Hong James Goh, Pujiang Shi, Hee Kit Wong, Yong Zhang, Sunny Akogwu Abbah, Jun Li


Singapore Patent Filed


Goh, C. H. J., Shi, P., Hui, H. P. J., & Li, J. Tissue Interface Augmentation Device for Ligament/Tendon Reconstruction.


Publication number: 11201510659T


Abstract: The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material.


Filed: July 21, 2014

National Phase Entry Date: December 24, 2015

Publication date: Jan 28, 2016

Applicants: National University of Singapore, Agency for Science, Technology and Research

Inventors: Cho Hong James GOH, Kok Hiong Thomas TEH, Pujiang SHI, Hoi Po James HUI, Jun LI


European Patent Filed


Goh, C. H. J., Shi, P., Hui, H. P. J., & Li, J. Tissue Interface Augmentation Device for Ligament/Tendon Reconstruction.


Publication number: 14 826 226.4


Abstract: The present invention relates to a device for the interfacial augmentation of tissue grafts for the purpose of tendon and ligament reconstruction. The inventive device works both as a delivery vessel for osteoconductive and osteoinductive factors and as a scaffold to stimulate and support bone ingrowth and comprises a tubular composite silk sheath, said tubular composite silk sheath comprising: a backbone consisting of a tubular silk mesh, and a carrier material consisting of a porous silk sponge, wherein said tubular silk mesh consists of degummed silk fibroin fibers, wherein said porous silk sponge comprises silk fibroin fibers and hydroxyapatite particles and said tubular silk mesh and said porous silk sponge form a composite material.


Filed: July 21, 2014

Regional Phase Entry Date: January 13, 2016

Publication date: May 25, 2016 Bulletin 2016/21

Applicants: National University of Singapore, Agency for Science, Technology and Research

Inventors: Cho Hong James GOH, Pujiang SHI, Hoi Po James HUI, Jun LI

Achievements: About

COMPETITIVE GRANTS AWARDED

  • Development of Novel Yolk-Shell Nanoparticle Based Moldable Putty for Surgery. JCH Goh and HK Wong, J Li, Y Zhang (2011 – 31/05/2013) $ 249,574.00, A*STAR, SERC (BEP).


  • Silk Sleeve Device for Improving the Graft Bonding at the Bone Tunnel for Anterior Cruciate Ligament (ACL) Reconstruction. JCH Goh and JHP Hui, J Li (01/09/2013 – 28/02/2017) $ 1,353,900.00, A*STAR, SERC (BEP).


  • Tissue Engineering of the Intervertebral Disc – Regenerating the Annulus Fibrosus with Electrospinning and Physiologically Mimetic Culture. SL Toh (17/07/2012 – 31/03/2016) $ 523,000.00, MOH:NMRC.


  • Development of cells and bioactive molecules discharging technology for cardiac tissue repair. SL Toh (2014 – 2017) MOE Tier 1.


  • Dimensional Control of 3D-Printable Silk-Based Structures through Physical Cues. JCH Goh (15/03/16 – 14/03/19) $ 175,000.00, MOE (AcRF) Tier 1-FRC.

Achievements: About

RESEARCH PRIZES/AWARDS

  • Finalist for Savio L-Y. Woo Young Researcher Award

S.N. Png, P. Shi, X. Ren, J.H.P. Hui, J. Li and J.C.H. Goh. Preclinical Evaluation of the Silk-based Sheath for Enhanced Osteointegration of Tendon Graft Post Anterior Cruciate Ligament Reconstruction. (16th International Symposium on Ligaments and Tendons, San Diego, California, USA, 18 March 2017)


  • Savio L-Y. Woo Young Researcher Award (Translational Research)

Shi P, Ren X, Hui JHP, Li J and Goh JCH. Augmentation of Tendon Graft Anterior Cruciate Ligament Reconstruction Outcome Using a Silk Based Osteoconductive Sheath. International Symposium on Ligaments & Tendons (15thInternational Symposium on Ligaments and Tendons, Orlando, USA, 4 March 2016).


  • Bronze Medal Award: Undergraduate Category, Oral Presentation

SYJ Chong, PY Neo, SL Toh and JCH Goh, "Adapting the Layer-by-Layer Deposition Technique using Silk Fibroin and Chitosan for Annulus Fibrosus Tissue Engineering". Biomedical Engineering Society (Singapore) 9th Scientific Meeting. 16 May 2015. Singapore.


  • SYIS Poster Presentation Award

Neo PY, Goh JC, Toh SL. The Use Of Adipose-Tissue Derived Stem Cells And Highly Hierarchical Silk Laminates With Nanotopography For Annulus Fibrosus Tissue Engineering. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Asia Pacific Meeting. September 24-27, 2014. Daegu, South Korea.


  • Gold Medal Award: Graduate Category, Oral Presentation

Neo PY, Shi P, Goh JC, Toh SL. Intervertebral Disc Tissue Engineering: Towards Complete Disc Replacement with Silk/PVA Hydrogels. Biomedical Engineering Society (Singapore) 8th Scientific Meeting. May 17, 2014. Singapore.


  • Silver Medal Award: Undergraduate Category, Oral Presentation

DJ Tan, PY Neo, JCH Goh and SL Toh, "Development of a Novel Anisotropic Composite Silk Scaffold For Annulus Fibrosus Tissue Engineering". Biomedical Engineering Society (Singapore) 8th Scientific Meeting. 17 May 2014.  Singapore.


  • Finalist for Young Investigator Awards

P. Shi, X. Ren, J.H.P. Hui, S.L. Toh, J.C. Goh. Ligament-to-bone Interface Tissue Regeneration using a Functionalized Biphasic Silk Fibroin Scaffold. (15th International Conference on Biomedical Engineering 2013, Singapore, 4-7 December 2013)


  • Silver Award: Graduate Category, Technical (Oral) Presentation

Neo PY, Toh SL, Goh JC. The Effect of Hyperconfluent Culture Duration on Differentiation Capabilities of Adipose-Derived Mesenchymal Stem Cells. Biomedical Engineering Society (Singapore) 6th Scientific Meeting. May 19, 2012. Singapore.


  • Oral Presentation Award

Neo PY, See EY, Toh SL, Goh JC. Multi-lineage Potential of Cell-Sheets: A Comparative Study using Adipose-Tissue Derived Stem Cells. 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering. December 12-14, 2011. Singapore.

Achievements: About

INTERNATIONAL CONFERENCES

  • Pujiang Shi, Si Ning Png, Xiafei Ren, James H.P. Hui, Jun Li and James C.H. Goh. Augmentation of Tendon Graft Anterior Cruciate Ligament Reconstruction Outcome Using a Silk Based Osteoconductive Sheath. (15th International Symposium on Ligaments and Tendons, Orlando, USA, 4 March 2016.)

  • Neo PY, Toh SL, Goh JC. Combinatorial Approach for Annulus Fibrosus Tissue Engineering Using Silk-Based Laminates, Adipose-Derived Stem Cells and Cell-Sheet Technology. Orthopaedic Research Society (ORS) 2016 Annual Meeting. March 5-8, 2016.Orlando, USA. (Oral)

  • Pujiang Shi, Xiafei Ren, James H.P. Hui, Jun Li, James C.H. Goh. Silk-Based Osteoconductive Sheath for Enhanced Osteointegration of Tendon Graft Post Anterior Cruciate Ligament Reconstruction. (Orthopaedic Research Society (ORS) 2016 Annual Meeting. Orlando, USA. 5-8 March, 2016.) 

  • Maria Christine Tankeh Asuncion, Siew-Lok Toh, James C.H. Goh. Fabrication and characterization of anisotropic silk fibroin/gelatin scaffolds using unidirectional freezing.  (MEDICON 2016-XIV Mediterranean Conference on Medical and Biological Engineering and Computing.  Paphos, Cyprus. 31 March-2 April 2016.)

  • Pujiang Shi, Kelei Chen, Xiafei Ren, Siew-Lok Toh, James H.P. Hui, Jun Li, James C.H. Goh. Silk scaffold with osteoconductive and osteoinductive cues for enthesis regeneration in anterior cruciate ligament reconstruction. (International Symposium on Ligaments & Tendons – XIV. Las Vegas, USA, 27 March 2015.)

  • Pujiang Shi, Kelei Chen, Xiafei Ren, Siew-Lok Toh, James H.P. Hui, Jun Li, James C.H. Goh. Silk/Hydroxyapatite Composite Scaffold for Soft-to-Hard Tissue Interface Regeneration in Anterior Cruciate Ligament Reconstruction. (Orthopaedic Research Society (ORS) 2015 Annual Meeting. Las Vegas, USA. 28-31 March, 2015.)

  • Maria Christine Tankeh Asuncion, Siew-Lok Toh, James C.H. Goh. The promotion of cardiomyogenic differentiation of pBMSCs thru 5-azacytidine and ascorbic acid exposure.  (WACBE 2015-7th World Congress on Bioengineering. Singapore, Singapore. 6-8 July 2015.)

  • Siew-Lok Toh, James C.H. Goh. Silk-based scaffolds for Tissue Engineering Applications. (International Conference for Innovation in Biomedical Engineering and Life Sciences. Putrajaya, Malaysia. 6-8 December 2015.)

  • Neo PY, Tay ASR, Chong JSY, Goh JC, Toh SL. Hierarchical Silk-Based Laminates for Annulus Fibrosus Tissue Engineering. The 5th International Conference on Bio-based Polymers (ICBP2015).  June 24 – 27, 2015. Singapore. (Oral)

  • Maria Christine Tankeh Asuncion, Siew-Lok Toh, James C.H. Goh. Unidirectionally-frozen silk/gelatin scaffolds for cardiac tissue engineering. (IUPESM 2015-World Congress on Medical Physics and Biomedical Engineering. Toronto, Canada. 7-12 June 2015.)

  • Neo PY, Tay ASR, Chen XJ, Goh JC, Toh SL. Tissue Engineering Silk-doped PVA Hydrogels for Intervertebral Disc Replacements: From a Biomechanics Perspective. 7th WACBE World Congress on Bioengineering. July 6-8, 2015. Singapore. (Oral)

  • Neo PY, Goh JC, Toh SL. Tissue Engineering a Mechanically Robust De Novo Intervertebral Disc Using Silk-Based Biomaterials, Adipose-derived Stem Cells and Physiologically Mimetic Culture. Orthopaedic Research Society (ORS) 2015 Annual Meeting. March 28-31, 2015. Las Vegas, USA. (Oral)

  • Neo PY, Shi P, Goh JC, Toh SL. The Use of Silk/PVA Cryogels for Intervertebral Disc Replacements: Tissue Engineering from a Biomechanics Perspective. International Conference on Experimental Mechanics. November 15-17, 2014. Singapore. (Oral)

  • Neo PY, Shi P, Goh JC, Toh SL. The Use Of Silk/PVA Hydrogels For Nucleus Pulposus Tissue Engineering: Towards Whole Disc Replacement. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Asia Pacific Meeting. September 24-27, 2014. Daegu, South Korea. (Poster)

  • Neo PY, Goh JC, Toh SL. The Use of Adipose-Tissue Derived Stem Cells and Highly Hierarchical Silk Laminates with Nanotopography for Annulus Fibrosus Tissue Engineering. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Asia Pacific Meeting. September 24-27, 2014. Daegu, South Korea. (Poster)

  • Pujiang Shi, Kelei Chen, Xiafei Ren, Siew-Lok Toh, James H.P. Hui, Jun Li, James C.H. Goh. Bioactive silk scaffold for graft-bone interface regeneration in anterior cruciate ligament reconstruction. (Tissue Engineering and Regenerative Medicine International Society (TERMIS) – Asia Pacific Chapter 2014 Annual Conference. Daegu, Korea, 24-27 September 2014.)

  • P. Shi, X. Ren, J.H.P. Hui, S.L. Toh and J.C.H. Goh. A Preclinical Evaluation of the Functionalized Biphasic Silk Fibroin Scaffold for Complete Bone- Ligament-Bone Regeneration. (Orthopaedic Research Society (ORS) 2014 Annual Meeting. New Orleans, USA. 15-18 March, 2014.)

  • J.C. Goh., S.L. Toh. Rehabilitative mechanical conditioning regime for the development of tissue engineered tendon/ligament. (Orthopaedic Research Society ORS 2013 Annual Meeting, San Antonio, Texas, USA, 26-29 January 2013)

  • S.L. Toh, J.C. Goh. Control of Rabbit Mesenchymal Stem Cells Differentiation Lineage through Rehabilitative Mechanical Conditioning Regime for the Development of Tissue Engineered Tendon/Ligament. (International Society for Stem Cell Research ISSCR Regional Forum Series 2013, Florence, Italy, 15-18 September 2013) 

  • E.Y. Teo, J.X. Yang, N.B. Johana, J.C. Goh, J.K.Y Chan. The Effects of SDF1 in Vasculogenesis of Endothelial Colony Forming Cells and Human Fetal Mesenchymal Stem Cells Co-culture System for Tissue Engineered Bone Grafts. (International Society for Stem Cell Research ISSCR Regional Forum Series 2013, Florence, Italy, 15-18 September 2013)

  • P. Shi, X. Ren, J.H.P. Hui, S.L. Toh, J.C. Goh. Bioactive Silk Scaffold for Regeneration of the Native Bone-Ligament-Bone Tissue Zones. (Tissue Engineering and Regenerative Medicine International Society – Asia Pacific Chapter 2013 Annual Conference, Shanghai and Wuzhen, PR China, 23 – 26 Oct 2013)

  • P. Shi, X. Ren, J.H.P. Hui, S.L. Toh, J.C. Goh. Ligament-to-bone Interface Tissue Regeneration using a Functionalized Biphasic Silk Fibroin Scaffold. (15th International Conference on Biomedical Engineering 2013, Singapore, 4-7 December 2013.)

  • Neo PY, Shi P, Toh SL, Goh JCH. Tissue Engineering the Intervertebral Disc: A Whole Disc Approach Using Silk-Derived Scaffolds and Hydrogels with Adipose-Derived Stem Cells. 15th International Conference on Biomedical Engineering (ICBME). December 4-7, 2013. Singapore. (Oral)

  • Shi, P., Ren, X., Hui, J. H. P., Toh, S. L., & Goh, J. C. H. (2013, November). Ligament-to-bone interface tissue regeneration using a functionalized biphasic silk fibroin scaffold. In The 15th International Conference on Biomedical Engineering: ICBME 2013, 4th to 7th December 2013, Singapore (Vol. 43, p. 64). Springer Science & Business Media.

  • Shi P, Abbah SA, Saran K, Zhang Y, Li J, He P, Chuah YJ, Wong HK, Goh JCH. Silk Fibroin Based Biomaterials for Bone/Bone Tunnel Regeneration, (International Bone-Tissue-Engineering Congress 2013, 16 -19 December 2013) (Oral, Singapore)

  • Neo PY, Shi P, Toh SL, Goh JCH. Tissue Engineering the Intervertebral Disc with Adipose-Tissue Derived Stem Cells and Silk-Derived Biomaterials. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Asia Pacific Meeting. October 23-26, 2013. Shanghai, China. (Oral)

  • Neo PY, Goh JC, Toh SL. Tissue Engineering a De Novo Annulus Fibrosus - Combining Adipose-Tissue Derived Mesenchymal Stem Cells with Electrospun Silk Mats and Chondrogenic Induction Culture. Orthopaedic Research Society (ORS) 2013 Annual Meeting.  January 26-29, 2013.  San Antonio, USA. (Poster)

  • P. Shi, S.L. Toh, J.C. Goh. BMP-2 Eluting Biphasic Hybrid Silk Scaffold for Ligament and Bone Tunnel Regeneration. (12th International Symposium on Ligaments and Tendons, San Francisco, California, USA, 3 February 2012)

  • P. Shi, S.L. Toh, J.C. Goh. Biphasic Hybrid Silk Scaffold for Ligament Regeneration and Bone Tunnel Healing in the Rabbit Model. (Singapore Biomedical Engineering Student Symposium (BES) 6th Scientific Meeting, Singapore, 19 May 2012)

  • Neo PY, See EY, Toh SL, Goh JC. The Use of Adipose Derived Stem Cells and Cell-Sheets for Inner and Outer Annulus Fibrosus Regeneration. 3rd TERMIS World Congress. September 5-8, 2012. Vienna, Austria. (Poster)

  • P. Shi, S.L. Toh, J.C. Goh. Effects of BMP-2 Eluting Biphasic Silk Scaffold on Ligament Regeneration and Bone Tunnel Healing in Rabbits. (3rd Tissue Engineering and Regenerative Medicine International Society World Congress 2012, Vienna, Austria, 5-8 September 2012)

  • P. Shi, X. Ren, J.H.P. Hui, S.L. Toh, J.C. Goh. Functionalized Biphasic Silk Scaffold for Anterior Cruciate Ligament Regeneration and Bone Tunnel Healing in the Porcine Model. (3rd Tissue Engineering and Regenerative Medicine International Society World Congress 2012, Vienna, Austria, 5-8 September 2012)

  • Neo PY, See EY, Toh SL, Goh JC. Adipose-Tissue Derived Stem Cells Cell-Sheets for Regeneration of the Annulus Fibrosus. 9th World Biomaterials Congress (WBC). June 1-5, 2012. Chengdu, China. (Oral)

  • Neo PY, See EY, Toh SL, Goh JC. Multi-lineage Potential of Cell-Sheets: A Comparative Study using Adipose-Tissue Derived Stem Cells. 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering. December 12-14, 2011. Singapore. (Oral)

  • Neo PY, See EY, Toh SL, Goh JC. Cell-sheet Tissue Engineering: A Characterization and Multilineage Potential Study of Adipose Tissue Derived Stem Cells Cell-Sheets. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Asia Pacific Meeting. August 3-5, 2011. Singapore. (Poster)

Achievements: About

INVITED CONFERENCE TALKS

  • Keynote Speaker: Goh JCH. Tissue Engineering of Ligaments and Tendons. 9th World Congress on Biomaterials, 1 – 5 June 2012, Chengdu, China

  • Keynote Speaker: Goh JCH. Next Phase in Musculoskeletal tissue repair. 3rd International Symposium on Regenerative Medicine, 25-26 July 2012, Daegu, Korea

  • Symposium Speaker: Goh JCH “Enhancing Bioengineering Education through Cross-Cultural and Cross-Discipline Learning Experiences”. The 34th Annual International Conference of the Engineering in Medicine and Biology Society, August 28th -September 1, 2012, Hilton Bayfront Hotel, San Diego, California, USA.

  • Symposium Speaker: Goh JCH “Tissue Engineering Education: South-east Asia Perspective” Education Symposium at TERMIS World Congress, Sept 5-8, 2012, Vienna, Austria

  • Keynote Speaker: Goh JCH. 7th International Conference on Biomedical Engineering and Medical Applications (ICBEMA), November 9-10, 2012 in Jakarta, Indonesia

  • Keynote Speaker: Goh JCH. “The Career paths for Biomedical Engineers” and “Funding for Translational Research in Singapore”. Biomedical Engineering International Conference 2012 (BME2012) December 5-8, 2012, Kowloon, Hong Kong.

  • Keynote Speaker: Goh JCH. “Of Cells, Scaffolds and Growth Factors in Regenerative Medicine” Stem Cell and Regenerative Medicine Conference Feb. 22, 2013 Seoul, Korea

  • Keynote Speaker: Goh JCH, “Biomechanical Considerations in Tissue Engineering of Ligaments and Tendons” 7th World Congress of Biomechanics, July 6 - 11, 2014, Boston, USA

  • Plenary Speaker: Goh JCH, “Engineering Innovations for Clinical Applications” 1st Global Conference on Biomedical Engineering (GCBME 2014) in conjunction with the 9th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2014) , 9-12 October 2014, National Cheng Kung University, Tainan, Taiwan.

  • Invited Speaker. Goh JCH.  Biomechanical Consideration for Intervertebral Disc Tissue Engineering”. Workshop on Engineering for Life Science.   18, March 2015, University of Tokyo, Japan.

  • Symposium Speaker: Goh JCH “Biomechanical Consideration for IVD Tissue Engineering” 25th Congress of the International Society of Biomechanics, 12-17 July 2015, Glasgow, UK.

  • Plenary Speaker. Goh JCH. "Silk-based Scaffolds for Tissue Engineering Applications". International Conference for Innovation in Biomedical Engineering and Life Sciences (ICIBEL 2015), 6th - 8th December, 2015, Putrajaya, Malaysia.

  • Special Lecture: Goh JCH. “Silk Biomaterials for Regenerative Medicine”. Tissue Engineering and Regenerative Medicine International Society-Asia-Pacific (TERMIS AP 2016), 3-6 Sept 2016, Tamsui, Taiwan

  • Keynote Speaker: Goh JCH “Biofabrication of Scaffolds for Musculoskeletal Tissue Engineering” International Conference on Bio-fabrication and Bio-monitoring (ICBB 2016), 12-14 October 2016, Taipei, Taiwan

  • Plenary Speaker. Goh JCH. “Emerging trends in Musculoskeletal Biomechanics in relation to Tissue Repair and Regeneration”. CLAIB 2016-VII Latin-American Congress on Biomedical Engineering, 26-28 October 2016, Bucaramanga, Colombia

  • Invited Speaker: Goh JCH “Mesenchymal Stem Cells Exosome Therapy – From Basic Science to Clinical Application”. 1st Open Scientific Meeting Stem Cells & Tissue Engineering Research Center IMERI-FKUI, 17-18 Nov, Jakarta, Indonesia

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